Zycel 100 mg (Celecoxib)

What is Zycel 100 mg?

Zycel 100 mg is a brand-name medication that contains celecoxib, a nonsteroidal anti-inflammatory drug (NSAID). It is primarily used to treat pain and inflammation associated with various conditions such as arthritis. Zycel belongs to the COX-2 selective inhibitor class, which provides anti-inflammatory effects with a reduced risk of gastric ulcers compared to traditional NSAIDs.

Uses of Zycel 100 mg

Zycel 100 mg is used for the treatment and management of:

• Osteoarthritis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Acute pain (e.g., postoperative or musculoskeletal pain)

• Primary dysmenorrhea (menstrual cramps)

Benefits of Zycel 100 mg

• Provides effective pain relief and reduces inflammation.

• Has lower gastrointestinal toxicity compared to non-selective NSAIDs like ibuprofen or diclofenac.

• Offers once or twice daily dosing for convenience.

• Suitable for long-term use under medical supervision for chronic inflammatory conditions.

How Does Zycel 100 mg Work?

Zycel (celecoxib) works by selectively inhibiting the COX-2 enzyme, which is responsible for the production of prostaglandins—chemical messengers that promote pain and inflammation. By blocking COX-2 (and sparing COX-1), Zycel reduces inflammation and pain with a lower risk of gastric ulceration and bleeding.

How to Take Zycel 100 mg

• Take orally with or without food; food may help reduce stomach discomfort.

• Swallow the capsule whole with water.

• Follow your doctor’s dosage schedule—do not exceed the prescribed dose.

• Avoid alcohol while taking NSAIDs, as it increases the risk of GI side effects.

Dosage of Zycel 100 mg

Typical dosing (subject to medical advice):

• Osteoarthritis: 100 mg twice daily or 200 mg once daily.

• Rheumatoid arthritis: 100–200 mg twice daily.

• Acute pain/dysmenorrhea: 400 mg initially, followed by 200 mg if needed on day 1; then 200 mg twice daily as needed.

• Ankylosing spondylitis: 200 mg once daily or 100 mg twice daily.

Always use the lowest effective dose for the shortest duration to minimize risk.

Missed Dose and Overdose

Missed dose:

• Take it as soon as you remember.

• If it’s near your next dose, skip the missed one—do not double the dose.

Overdose:

• Symptoms may include nausea, vomiting, drowsiness, stomach pain, or difficulty breathing.

• Seek immediate medical attention in case of overdose.

Available Strengths

• Zycel is commonly available in:

  • 100 mg capsules

  • 200 mg capsules

Side Effects of Zycel 100 mg

Common side effects:

• Indigestion

• Abdominal pain

• Nausea

• Headache

• Diarrhea

• Dizziness

Serious (rare) side effects:

• Gastrointestinal bleeding or ulcer

• Heart attack or stroke (especially with long-term use or in high-risk patients)

• Kidney dysfunction

• Severe allergic reactions

Interactions of Zycel 100 mg

Zycel may interact with:

• Anticoagulants (e.g., warfarin): Increased bleeding risk

• ACE inhibitors/ARBs: May reduce kidney function

• Diuretics: Reduced efficacy

• Lithium: Increased lithium levels

• Fluconazole: May increase celecoxib levels

Avoid combining with other NSAIDs unless directed by a physician.

Precautions

• Not recommended in patients with:

  • History of heart attack or stroke

  • Peptic ulcer disease or gastrointestinal bleeding

  • Severe liver or kidney disease

• Use with caution in:

  • Hypertension

  • Asthma

• Avoid during pregnancy (especially in the third trimester) and breastfeeding, unless advised by a healthcare provider.

Storage Information

• Store below 25°C (77°F).

• Keep away from moisture and direct sunlight.

• Keep out of reach of children.

Availability

• Zycel 100 mg is available by prescription in various countries, including India and several Asian and Middle Eastern markets.

• Availability may vary based on regulatory approvals in different regions.

Frequently Asked Questions (FAQs)

1. Is Zycel 100 mg safe for long-term use?

Long-term use should be monitored closely due to potential cardiovascular and renal risks.

2. Can I take Zycel with paracetamol?

Yes, they work via different mechanisms and are often used together for enhanced pain relief.

3. Is Zycel 100 mg suitable for back pain?

Yes, it is commonly prescribed for musculoskeletal pain, including lower back pain.

4. Can I drive after taking Zycel?

Usually yes, but avoid driving if you feel dizzy or drowsy.

5. Can Zycel be taken during menstruation?

Yes, it is effective for relieving menstrual cramps (dysmenorrhea).