What is Gestone 400?
Gestone 400 is an injectable formulation of natural micronized progesterone, containing 400 mg per 2 ml ampoule (i.e., 200 mg/ml). It is used primarily in women for hormonal support during fertility treatments and early pregnancy maintenance. Progesterone is essential in regulating the menstrual cycle, supporting implantation, and maintaining early pregnancy.
What are the Uses of Gestone 400 (Progesterone)?
Gestone 400 is used to treat or support several reproductive and hormonal conditions:
Luteal phase support in assisted reproductive technologies (ART), such as IVF
Support for early pregnancy, especially in women with recurrent miscarriage or luteal phase deficiency
Treatment of secondary amenorrhea
Management of dysfunctional uterine bleeding
As part of hormone replacement therapy (HRT) in combination with estrogen
Prevention of preterm birth (off-label use)
What are the Benefits of Gestone 400 (Progesterone)?
Enhances uterine lining to support embryo implantation
Helps prevent miscarriage in cases of progesterone deficiency
Regulates the menstrual cycle
Counteracts estrogen’s effect on the endometrium in HRT
May help prevent preterm labor in some high-risk pregnancies
How Does Gestone 400 Work?
Gestone 400 works by supplementing or replacing the body’s natural progesterone. Its effects include:
Preparing the endometrial lining of the uterus for pregnancy
Maintaining a favorable hormonal environment during early gestation
Inhibiting uterine contractions to support embryo implantation
Restoring hormonal balance in menstrual irregularities
How to Take Gestone 400 (Progesterone)?
Route: Intramuscular (IM) or subcutaneous (SC) injection
Frequency: Usually once daily or as directed by your fertility specialist
Administration: Injected in the gluteal muscle or thigh, ideally by a healthcare professional
Dosage of Gestone 400
Typical dosing:
IVF or fertility support: 100–400 mg daily depending on protocol
Pregnancy support: 200–400 mg daily for the first trimester
Amenorrhea: 5–10 days of treatment cycles at your doctor’s discretion
Always follow the dosage instructions provided by your fertility specialist or gynecologist.
Missed Dose and Overdose
Missed Dose: Administer as soon as possible. Skip it if the next scheduled dose is near. Do not double the dose.
Overdose: Symptoms may include nausea, dizziness, or drowsiness. Seek immediate medical attention.
Available Strengths of Gestone (Progesterone)
Gestone 100 mg/ml
Gestone 200 mg/ml (Gestone 400 is 2 ml of 200 mg/ml = 400 mg total)
Side Effects of Gestone 400
Common Side Effects:
Pain, swelling, or irritation at injection site
Mood swings or irritability
Bloating and fatigue
Less Common but Serious:
Allergic reactions (rash, difficulty breathing)
Blood clots (leg pain, chest pain)
Jaundice
Vision disturbances
Depression or mental changes
Drug Interactions
Gestone 400 may interact with:
Antiepileptic drugs (phenytoin, carbamazepine)
Antibiotics (rifampin)
Herbal remedies like St. John’s Wort
Estrogen-containing medications
Always inform your doctor of all medications and supplements you’re using.
Precautions and Warnings
Not suitable for patients with breast cancer, active thromboembolism, or severe liver disease
Use cautiously in patients with depression, migraines, hypertension, or asthma
Not recommended during breastfeeding unless directed by your doctor
Requires close medical supervision during long-term use
Storage Information
Store below 25°C (77°F)
Protect from light and moisture
Do not freeze
Keep out of reach of children
Availability in the US and Australia
USA: Gestone 400 may not be directly available. Similar products like progesterone in oil (PIO) injections or vaginal progesterone (Endometrin, Crinone) are widely used.
Australia: Progesterone injectable preparations may be available by prescription through fertility clinics under alternate brand names.
Frequently Asked Questions (FAQs)
Q1. Is Gestone 400 safe in pregnancy?
Yes, it’s commonly used to support early pregnancy, especially in women undergoing IVF or with prior pregnancy losses.
Q2. How long should Gestone 400 be used during IVF?
Typically from the day of embryo transfer and continued up to 10–12 weeks of pregnancy, depending on progesterone levels.
Q3. Is there a pain-free alternative to injections?
es. Vaginal forms like Utrogestan, Susten, or Crinone offer similar hormonal support.
Q4. Can I inject Gestone 400 at home?
Yes, but it should be done by someone trained. IM injections are deep and may be painful without proper technique.
Q5. Will it delay my period?
Yes. Progesterone can delay menstruation as long as it is being administered. Withdrawal bleeding typically occurs after stopping.
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